News

Our Blog

Cannabis effects and therapeutic cues: Part 1 The “Munchies”

[vc_row][vc_column][vc_column_text]

Cannabis Effects and Therapeutic Cues – Part 1 The “Munchies”

The ‘Munchies’, a term well associated with the insatiable desire to eat when under the influence of Cannabis, is caused by a various array of physiological events which lead to the stimulation of hunger. This is accompanied by, and often preceded by, feelings of euphoria as a result of the activation of certain cannabinoid receptors. Studying the ‘Munchies’ effect has developed a greater deal of understanding in the role of the endocannabinoid system (ECS) and appetite stimulation. However much still remains a mystery in this area. Further investigation of the intricate interplay between various cellular signalling pathways could be the key to finding novel ways to treat various eating disorders such as anorexia, cachexia and obesity; as various studies have implicated the role of the ECS in the aforementioned diseases [1].

It is widely accepted that the smell of food causes the stimulation of appetite [2]. Agonism or stimulation of the CB1 receptor dampens the effect of the negative feedback system present in the olfactory cortex, and this double negative effect leads to an enhanced sense of smell [3]. Therefore people experiencing the ‘high’ have an augmented sensory response to odour, and tend to have a higher appreciation of food than usual. This olfactory pathway is presently being used to give appetite suppressing effects through an aromatherapy technique that involves the smelling of a strong fragrance (such as Vanilla or grapefruit) for more than five minutes, to magnify the negative feedback loop on the olfactory bulb.

Appetite-stimulation
Figure 1: The negative feedback loop of the olfactory cortex acting on the olfactory bulb, and how stimulation of the CB1 receptor inhibits this loop

 

Cannabis has been shown to have its effect on appetite mainly through the CB1receptor. The CB1 receptor has been implicated in the olfactory system that triggers smell, but is also involved in the neuronal signalling that triggers the sense of hunger and satiety[4]. Therefore it can be a key regulator in […]

[/vc_column_text][vc_row_inner][vc_column_inner width=”1/3″][vc_column_text css=”.vc_custom_1479228376428{margin-bottom: 15px !important;}”]View the PDF:[/vc_column_text][vc_single_image image=”16773″ img_size=”full” alignment=”center” style=”vc_box_shadow” onclick=”custom_link” link=”/wp-content/uploads/2016/10/RD_Publications_The-Munchies.pdf”][/vc_column_inner][vc_column_inner width=”1/3″][/vc_column_inner][vc_column_inner width=”1/3″][/vc_column_inner][/vc_row_inner][/vc_column][/vc_row]

    Video: “The Scientist” – A documentary....
  • “The Scientist” is a do

  • An interview with Vincenzo Di Marzo,....
  • Professor Di Marzo is one o